MET2 — Candida albicans

Summary

CR_02170W_A (MET2) on Candida albicans chromosome 8 encodes a protein with homoserine O-acetyltransferase, L-serine O-succinyltransferase, L-serine O-acetyltransferase, and deacetylcephalosporin-C acetyltransferase activities, belonging to the AB_hydrolase and HAT_MetX-like families. The gene is associated with L-methionine anabolism, adenine anabolism, GMP anabolism, ergosterol metabolism, sterol metabolism, homoserine metabolism, sulfur amino acid metabolism, mRNA breakdown, host invasion, antibody production, and immune response. Its product localises to the mitochondria, cytoplasm and cytosol. MET2 is linked to decreased viability, respiratory growth, sporulation, autophagy, mitophagy, pexophagy, reticulophagy, nucleophagy, freeze-thaw and desiccation resistance, and increased chronological lifespan and chemical compound excretion. Abnormal nuclear and vacuolar morphology, protein/peptide modification and distribution, and decreased competitive fitness and metal resistance are also connected. Studies of related genes in other species link the family to unaffected pathogenicity, auxotrophy, and altered starvation and chemical resistance.