CDC4 — Candida albicans

Summary

CR_01680C_A (CDC4, also known as POP2/POP1) on Candida albicans chromosome 8 encodes a protein with an F-box domain and WD40 repeats, functioning as a ubiquitin ligase substrate adaptor with molecular sensor activity, dynein complex binding, microtubule plus-end binding, ubiquitin-protein transferase activity, and GTP binding. This gene is associated with SCF-dependent proteasomal ubiquitin-dependent protein breakdown, negative regulation of mitotic DNA replication initiation, germ tube formation, flocculation, conjugation with cellular fusion, glycogenolysis, threonine anabolism, response to arsenic and cadmium, phospholipid homeostasis, vesicle transport along microtubule, and mitotic spindle orientation. It localizes to the nuclear SCF complex, kinetochore, cytoplasmic microtubule, and coatomer. Phenotypic associations include increased mating type switching, absent mating efficiency, abnormal cell cycle progression through G1/S transition, decreased budding, increased sporulation, delayed exit from G0, and increased fermentative growth.