pmr1 — Candida albicans

Summary

CR_01640C_A (symbol pmr1) on Candida albicans chromosome 8 encodes a P-type cation-transporting ATPase with proton, potassium, sodium, manganese and calcium transporter activities, as well as ATP hydrolase activity and calcium ion binding. The gene is associated with monoatomic cation transport, including potassium ion export, sodium transport and manganese ion membrane transport, and with cell pH regulation and reduction. It has been linked to thigmotropism, protein kinase A and PKC activation, cytokine and IL-10 production, mannan anabolism, sucrose metabolism and demethylation. The encoded product localises to the Golgi membrane, ER membrane, plasma membrane cell tip, lipid raft, extracellular vesicle, nuclear envelope and fungal-type vacuole. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.