SLN1 — Candida albicans

Summary

CR_01000C_A (SLN1, also known as CaSLN1, TCSB, or CaTCSB) on chromosome 8 of Candida albicans encodes a protein with histidine kinase, HAMP, and response regulator domains, and is annotated as having osmosensor, peroxide sensor, phosphorelay sensor kinase, histidine phosphotransfer kinase, and ATP binding activities. This membrane-associated protein localizes to the cell tip, division site, and cytoplasm. SLN1 is associated with germ tube formation, filamentous growth, biofilm formation, flocculation, cell wall assembly, host invasion, responses to nutrients, farnesol, and reactive oxygen species, the high-osmolarity glycerol response pathway, mannan and glycerol biosynthesis, and regulation of calcium-independent cell-cell adhesion and phagocytosis. Phenotypic associations include altered osmotic stress resistance, cell cycle progression defects (including G1/S arrest and G2/M delays), decreased cytokinesis and cell fusion, increased respiratory metabolism, and changes in budding pattern, chitin deposition, and starvation resistance. Related genes in other species are linked to turgor pressure, oxidative stress response, and pathogenicity.