ACC1 — Candida albicans

Summary

CR_00640W_A (ACC1, also known as CaHFA1, CaACC1, CaCUT6, CUT6, or HFA1) on Candida albicans chromosome 8 encodes a protein with acetyl-CoA carboxylase, biotin carboxylase, pyruvate carboxylase, allophanate hydrolase, and urea carboxylase activities (EC 6.4.1.2, 6.3.4.14). The gene is associated with malonyl-CoA and long-chain fatty acid biosynthesis, gluconeogenesis, fermentation, biofilm formation, and mitotic nuclear membrane biogenesis. It localizes to mitochondria, cytoplasm, and cytosol. Phenotypic associations include altered endocytosis, cell death rate, replicative lifespan, cell cycle progression, vacuolar distribution, anaerobic growth, desiccation resistance, freeze-thaw resistance, nutrient uptake, nitrogen source utilization, adhesion, and radiation resistance. Related genes in other species link the family to acid sensitivity.