COX1 — Candida albicans

Summary

CaCOX1 (CM_00250W) on the Candida albicans mitochondrial chromosome encodes a protein with cytochrome-c oxidase activity and endonuclease activity, containing both cytochrome c oxidase subunit 1 and homing endonuclease domains. The gene product is localised to the mitochondrial inner membrane as part of respiratory chain complex IV, and is associated with aerobic respiration, electron transport coupled proton transport, mitochondrial electron transport from cytochrome c to oxygen, and oxidative phosphorylation. CaCOX1 is also linked to intron homing, mitochondrial transcription, RNA breakdown, secretion, and the anabolism of prostaglandins and fatty acids. Phenotypic associations include altered nitrogen source utilisation, absent spore wall formation, decreased mitochondrial transport, increased polyploidy, abnormal cell cycle progression, defective mating response, and increased mitophagy. Studies of related genes in other species link the family to oxidative stress response.