KDX1 — Candida albicans

Summary

CR_00120C_A (KDX1, also known as MKC1) on chromosome 8 of Candida albicans encodes a mitogen-activated protein kinase of the p38-like family, with protein serine kinase activity, ATP binding, and ERK1 annotation. This gene is associated with the stress-activated protein kinase (SAPK) signaling pathway, regulation of melanin and chitin anabolism, cell wall organization, calcium-mediated signaling, cellular thermotolerance, glycerol anabolism, and N-glycan processing. It is linked to systemic and disseminated candidiasis, and to traits including salt tolerance and oxidative stress response. Phenotypic associations include altered cell cycle progression, decreased septum formation, abnormal carbon source utilization, increased virulence, decreased polyploidy, abnormal aneuploidy, and increased sporulation rate. The protein localizes to the cytoplasm, nucleus, mitotic spindle pole body, and cell division site.