COX2 — Candida albicans

Summary

CM_00030W (COX2, CaCOX2) in Candida albicans encodes cytochrome c oxidase subunit 2, a copper-binding cupredoxin domain protein that is part of respiratory chain complex IV (cytochrome-c oxidase activity, EC 7.1.1.9) in the mitochondrial inner membrane. The gene is associated with ATP synthesis coupled electron transport, mitochondrial electron transport from cytochrome c to oxygen, and redox activity. COX2 is associated with decreased lifespan, absent respiratory metabolism, absent desiccation resistance, increased polyploidy, decreased ionizing radiation resistance, increased mutation frequency, delayed cell cycle progression, and altered mitophagy and ribophagy. Additional associations include hemopoiesis, immune response, cytokine production, phagocytosis, cell adhesion, signal transduction, secretion, memory, nuclear import, fatty acid and prostaglandin anabolism, and pH reduction. Related genes in other species include COX18, COA6, SHY1, and RCF1-3.