NAD1 — Candida albicans

Summary

CM_00060W (NAD1) in Candida albicans encodes a component of respiratory chain complex I, specifically a protein with NADH dehydrogenase and ubiquinone reductase activities (EC 7.1.1.2). This mitochondrial inner membrane protein is associated with oxidative phosphorylation from NADH to ubiquinone, aerobic respiration, and electron transfer. The gene has also been linked to ATP anabolism, polyamine transport, endocytosis, cell killing, and innate immunity. Studies of related genes in other species link them to NADH-ubiquinone oxidoreductase function, though this is not directly established for C. albicans. Located on the mitochondrial chromosome, NAD1 is part of the core energy metabolism machinery, with broader associations suggesting roles beyond respiration.