CI-1 — Candida albicans

Summary

C7_02840C_A (CI-1, ERG5) in Candida albicans encodes a C-22 sterol desaturase, a cytochrome P450 monooxygenase with heme and iron binding, classified as EC 1.14.19.41. This enzyme is localized to the ER membrane and perinuclear ER. The gene is associated with ergosterol and sterol biosynthesis, as well as terpenoid anabolism. It has been linked to quorum sensing, biofilm formation, filamentous growth in response to starvation and biotic stimuli, morphogenesis, and cellular response to starvation. Associations also include hypersensitivity, protein synthesis, and abnormal plasma membrane morphology. Phenotypic connections involve decreased endocytosis, absent micronucleophagy, abnormal telomere length, decreased meiosis, increased cell death, and altered cell cycle progression, including G2/M phase delay and M phase arrest. Related genes in other species are linked to reduced virulence and acid sensitivity.