ARG4 — Candida albicans

Summary

Candida albicans ARG4 (C7_03570W_A) encodes an argininosuccinate lyase (EC 4.3.2.1), a cytosolic enzyme. The gene is associated with arginine metabolism and anabolism, the urea cycle, biofilm formation, homologous recombination, and hyphal growth. Phenotypic associations link ARG4 to altered biofilm formation, pseudohyphal and invasive growth, sporulation, mitotic recombination, mitochondrial genome maintenance, pexophagy, mitophagy, reticulophagy, endoplasmic reticulum and lipid particle morphology, protein/peptide modification, RNA accumulation, stress and metal resistance, desiccation resistance, respiratory growth, colony and liquid culture appearance, silencing, and both increased and decreased replicative and chronological lifespan. Studies of related genes in other species connect the family to nitrogen source utilization, endocytosis, respiratory growth, auxotrophy, and oxidative stress and toxin resistance.