AC1 — Candida albicans

Summary

AC1 (CYR1) on Candida albicans chromosome 7 encodes a large multidomain protein with adenylyl cyclase activity (EC 4.6.1.1), MAP kinase serine/threonine phosphatase activity, and metal-binding capacity, containing adenylate cyclase, leucine-rich repeat, and Ras-association domains. The gene is associated with the cAMP/PKA signaling cassette and GPCR signaling via cAMP second messenger, and is linked to responses to farnesol, hypoxia, carbon dioxide, and staurosporine. AC1 is associated with regulation of filamentous growth, phenotypic switching, cell-cell signaling, cell-abiotic substrate adhesion, pyruvate metabolism, fluconazole transport, and nitrogen catabolite repression. It localizes to the plasma membrane, endoplasmic reticulum, mitochondria, cytoplasm, and nucleus. Phenotypic associations include increased adhesion, altered filamentous and pseudohyphal growth, abnormal pheromone sensitivity and spore germination, increased fermentative and anaerobic growth, decreased lifespan, and altered cell cycle progression through G2/M.