ABC2 — Candida albicans

Summary

C7_02330W_A (ABC2, YCF1) in Candida albicans chromosome 7 encodes an ABC transporter, annotated as a GS-X pump with cadmium ion transmembrane transporter, haem-transporting ATPase, and ABC-type phytochelatin transporter activities, and binds ATP and heme. The protein localises to the fungal-type vacuole membrane, lipid raft, extracellular vesicle, Golgi complex, and plasmalemma. It is associated with fluconazole transport, glutathione transport into the vacuole, PC2 import into the vacuole, cellular detoxification of cadmium ion, heme export from vacuole to cytoplasm, response to metal, germ tube formation, sulfur amino acid metabolism, mRNA transcription, nitrogen utilization, and protein stabilization. The gene is linked to oxidative stress response and numerous phenotypes including altered vacuolar morphology, decreased endocytosis, increased pexophagy, and abnormal cell cycle progression.