DPP1 — Candida albicans

Summary

C7_02500C_A (DPP1, also known as DPP3) in Candida albicans chromosome 7 encodes a protein with DGPP phosphatase and phosphatidate phosphatase activity, belonging to the PA_PP_rel and P_Acid_Pase_2/haloperoxidase families. The gene is associated with farnesol anabolism, cAMP anabolism, sterol anabolism, ergosterol anabolism, phospholipid dephosphorylation, phospholipid metabolism, quorum sensing, biofilm formation, hyphal growth, germ tube formation, morphogenesis, fermentation, and secretion. It localises to the lipid raft, fungal-type vacuole membrane, ER membrane, and ER. DPP1 is linked to candidiasis and to oxidative stress response. Phenotypic associations include altered acid and alkaline pH resistance, increased chitin deposition, decreased viability and sporulation, increased cell size, cold sensitivity, decreased endocytosis, and changes in replicative and chronological lifespan.