CPH2 — Candida albicans

Summary

CaCPH2 (C7_02110W_A) encodes a chromatin regulatory protein containing PHD-type zinc finger domains, with molecular functions in zinc binding and bridging. The gene is associated with multiple biological processes including biofilm formation, hyphal and pseudohyphal growth, filamentous growth, cell morphogenesis, phagocytosis, TCA cycle, ergosterol and sterol anabolism, and chromatin-mediated maintenance of transcription. It is linked to regulation of transcription by RNA polymerase II, particularly negative regulation, and localizes to the nucleus, cytosol, mitotic spindle, and Rpd3S complex. CaCPH2 has been connected to numerous phenotypes including abnormal cell cycle progression, altered budding patterns, decreased colony size, increased X-ray resistance, abnormal silencing, and changes in fermentative metabolism, adhesion, endocytosis, mitophagy, and chitin deposition. Related genes in other species link the family to chromatin modification.