MAC1 — Candida albicans

Summary

C7_00510W_A, also known as MAC1, encodes a copper-fist family DNA-binding transcription activator on chromosome 7 of Candida albicans. The protein possesses DNA-binding transcription activator activity, RNA polymerase II-specific, and copper-binding molecular functions. MAC1 is associated with cellular copper and iron ion homeostasis, response to copper, alternative respiration, and chromatin modeling. It is linked to filamentous growth, mating, sexual reproduction, host invasion, cell death, and the regulation of transcription by RNA polymerase II. The gene is associated with the inflammatory response, innate immunity, and immune response, and has been linked to oral and disseminated candidiasis in humans and mouse models. MAC1 localizes to the nucleus, cytosol, and chromatin. Studies of related genes in other species link the family to copper homeostasis.