FLU1 — Candida albicans

Summary

C7_01520W_A (FLU1, also known as TPO1 or CaTPO1) in Candida albicans chromosome 7 encodes a major facilitator superfamily (MFS) transporter with xenobiotic, spermidine, and spermine transmembrane transporter activity. The gene is associated with fluconazole transport, putrescine transport, peptide transport, phospholipid transport, and xenobiotic detoxification by transmembrane export across the plasma membrane. It is also associated with mRNA transcription, nitrogen utilization and its regulation, single-species biofilm formation, response to stress, cellular response to oxidative stress, and chromatin modeling. The product localizes to the cellular bud membrane, fungal-type vacuole and its membrane, Golgi complex, endoplasmic reticulum, and plasmalemma. Associations with traits include oxidative stress response, and phenotypes linked to this gene include decreased pseudohyphal and invasive growth, abnormal cell cycle progression in G1 phase, decreased mating efficiency, abnormal colony and bud morphology, and decreased sporulation efficiency. Studies of related genes in other species connect the family to reduced virulence.