PFK1 — Candida albicans

Summary

C7_01800C_A (PFK1, also known as PFK2) in Candida albicans encodes a 6-phosphofructokinase, an enzyme with 6-phosphofructokinase activity. The gene is associated with glycolysis through fructose-6-phosphate, canonical glycolysis, aerobic respiration, and carbohydrate breakdown. It is linked to cellular response to glucose stimulus, cell pH regulation, vacuolar proton-transporting V-type ATPase complex assembly, and micropexophagy. Localisation evidence places the product in the cytoplasm, cytosol, mitochondria, and the external side of the mitochondrial outer membrane. Phenotypic associations include connections to fermentative growth, anaerobic growth, cell cycle progression, replicative lifespan, prion inheritance, desiccation resistance, freeze-thaw resistance, and nutrient uptake. Related genes in other species link the family to phosphate content and acid sensitivity.