CPCC — Candida albicans

Summary

C7_01330C_A (CPCC, also known as GCN2) in Candida albicans encodes a protein kinase with eukaryotic translation initiation factor 2alpha kinase activity, protein serine kinase activity, and additional molecular functions including cyclin binding, dsRNA binding, and tRNA binding. The gene is associated with responses to amino acid starvation, histidine, hydrogen peroxide, and N-acetyl-D-glucosamine, as well as regulation of translation initiation under stress, G1/G0 transition, and filamentous growth. It is linked to the large and small ribosomal subunits, the cytosolic ribosome, and spindle pole bodies. Phenotypic associations include increased virulence, altered cell cycle progression, abnormal spore germination, increased anaerobic growth, and changes in stress resistance, autophagy, and replicative lifespan. Related genes in other species connect it to GCN2-mediated signaling and regulation of translation in response to starvation.