PMR1 — Candida albicans

Summary

C7_00320C_A (PMR1) in Candida albicans chromosome 7 encodes a P-type ATPase with P-type ATPase activity, P-type potassium:proton transporter activity, K+-transporting ATPase activity, P-type sodium transporter activity, P-type manganese transporter activity, ABC-type manganese transporter activity, proton-transporting ATPase activity, P-type calcium transporter activity, calcium ion binding, ATP hydrolase activity, ATP binding, and metal binding. This gene is associated with Golgi calcium ion homeostasis, PKC activation, protein kinase A activation, cytokine production, thigmotropism, mannan anabolism, sucrose metabolism, and cellular mechanical stimulus response. It localizes to the Golgi membrane, endoplasmic reticulum, vacuolar membrane, plasma membrane cell tip, and nuclear envelope. PMR1 is linked to candidiasis and has been connected to numerous phenotypes including abnormal flocculation, decreased hypoosmotic stress resistance, altered cell cycle progression, increased necrotic cell death, and abnormal replicative lifespan. Studies of related genes in other species link the family to manganese and iron sensitivity.