LEU1 — Candida albicans

Summary

C7_00400W_A (LEU1, also known as LEU2) in Candida albicans encodes a 3-isopropylmalate dehydrogenase (EC 1.1.1.85) with NAD and magnesium binding activities. The gene is associated with regulation of morphogenesis, riboflavin anabolism, L-leucine anabolism, the glyoxylate cycle, mitotic recombination, and tRNA processing. It localizes to the cytosol and the fungal biofilm matrix. Phenotypic associations include delayed cytokinesis, increased aneuploidy, decreased invasive and pseudohyphal growth, altered cell cycle progression through G1/S, reduced autophagy, increased prion formation, decreased survival in stationary phase, and altered nutrient uptake and small molecule transport. Related genes in other species link the family to colony appearance.