NAG1 — Candida albicans

Summary

C6_04590C_A (NAG1) on Candida albicans chromosome 6 encodes a glucosamine-6-phosphate isomerase (EC 3.5.99.6), a member of the NagB/RpiA transferase-like family. The enzyme has glucosamine-6-phosphate deaminase activity and identical protein binding. It is associated with the breakdown of N-acetylneuraminate, glucosamine, N-acetylglucosamine, and chitin, as well as with carbohydrate metabolism, fermentation, and morphogenesis. The gene is linked to phenotypic switching, cell morphogenesis, regulation of gene expression, filamentous growth in response to biotic stimulus, hyphal growth, mating, and candidiasis. The product localises to the cytoplasm. Studies of related genes in other species link the family to glucose content.