DAC1 — Candida albicans

Summary

DAC1 (also known as NAGA or CaNAGA) on Candida albicans chromosome 6 encodes an N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25), a metal-binding amidohydrolase that catalyses the deacetylation of N-acetylglucosamine-6-phosphate. This gene is associated with the cellular response to N-acetyl-D-glucosamine and N-acetylglucosamine breakdown. DAC1 is linked to filamentous growth in response to chemical, starvation and biotic stimuli, as well as hyphal growth, phenotypic switching, cell morphogenesis, mating, and regulation of gene expression. It has also been connected to candidiasis.