CBS2 — Candida albicans

Summary

Candida albicans CBS2 (also known as SNF4) on chromosome 6 encodes a protein with protein kinase regulator and activator activity, including protein serine/threonine kinase activator activity, and binds AMP, ADP, and ATP. The product belongs to the AMPK gamma/SDS23 families and contains a CBS domain. CBS2 is associated with the regulation of stress responses, glycolytic process, and gluconeogenesis, as well as cellular responses to glucose starvation and starvation-induced filamentous growth. It is linked to mannan anabolism, cell aggregation, mating, signal transduction, peroxisome organization, the TCA cycle, and electron transport chain. The protein localizes to the cytoplasm, nucleus, plasma membrane, perinuclear space, and the nucleotide-activated protein kinase complex. Associations with numerous phenotypes include increased nutrient uptake, altered cell cycle progression, increased anaerobic growth, increased alkaline pH resistance, and decreased fermentative metabolism.