HOB1 — Candida albicans

Summary

Candida albicans gene HOB1 (also known as RVS167, CaHOB1, CaRVS167) on chromosome 6 encodes a protein containing a BAR domain and an SH3 domain, with cytoskeletal protein binding, cytoskeletal protein-membrane anchor activity, calmodulin binding, lipid binding, and identical protein binding functions. It is associated with plasma membrane tubulation, lipid tubulation, phosphatidylserine anabolism, regulation of endocytosis, actin cortical patch localization, actin filament organization, mitotic actomyosin contractile ring assembly, division septum assembly, hyphal growth, invasive growth, and filamentous growth in response to biotic stimulus. The gene is linked to copper sensitivity, abnormal septum formation, abnormal carbon and nitrogen source utilization, decreased rate of cytokinesis and cell cycle progression in M phase, increased adhesion, and absent cell fusion. The protein localizes to the actin cytoskeleton, cellular bud tip, mitotic actomyosin contractile ring, and the Rvs161p-Rvs167p complex.