ALS5 — Candida albicans

Summary

C6_03690W_A (ALS5) in Candida albicans chromosome 6 encodes a member of the agglutinin-like sequence (ALS) family of cell-surface glycoproteins, characterised by an adhesion domain superfamily fold and fibronectin-binding, laminin-binding, CAM-binding, HK-binding and peptide-binding molecular functions. The protein localises to the yeast-form and hyphal cell walls, the plasma membrane, extracellular vesicles and the extracellular space. ALS5 is associated with multiple biological processes including cell adhesion involved in biofilm formation (both single-species and multi-species), flocculation, cell aggregation, cell-matrix adhesion, adhesion of symbiont to host, iron acquisition from host, reductive iron assimilation, cellular copper ion homeostasis, ruffle assembly, detection of fungi and symbiotic fungi, innate immunity, and symbiont-mediated perturbation of host process. Related genes in other species link the family to host interaction and biofilm formation.