IVN1 — Candida albicans

Summary

C6_03660C_A (IVN1, also known as CDC50) in Candida albicans encodes a member of the CDC50/LEM3 family and is associated with aminophospholipid flippase and ATP hydrolase activities. The gene is linked to membrane biogenesis, phospholipid translocation, lipid transport and homeostasis, as well as biofilm formation, hyphal and filamentous growth, phagocytosis, endocytosis, homologous recombination, and the meiotic cell cycle. It localises to the plasma membrane, endoplasmic reticulum, Golgi, late endosome, and the APLT complex. Phenotypic associations include decreased flocculation, adhesion, and shmoo formation, abnormal filamentous and pseudohyphal growth, altered endocytosis, delayed cell cycle passage, and increased alkaline pH resistance. Studies of related genes in other species connect the family to zinc and acid sensitivity and oxidative stress response.