SAP1 — Candida albicans

Summary

C6_03490C_A (SAP1) in Candida albicans chromosome 6 encodes an aspartic endopeptidase (EC 3.4.23.24) belonging to the SAP-like aspartic peptidase A1 family, with metal-binding capability. The gene is associated with germ tube formation, transepithelial migration, phagocytosis, cytokine production (IL-6, IL-8, IGIF), acute inflammatory response, blood clotting, fibrinolysis, and release of cytochrome c from mitochondria. The product localizes to extracellular vesicles, the fungal cell wall, and the extracellular space. Related genes in other species are linked to hypervirulence, loss of pathogenicity, and disseminated candidiasis. The gene has been connected to oral, vaginal, and systemic candidiasis in mammalian models including humans, rats, mice, and guinea pigs.