SAP5 — Candida albicans

Summary

C6_03030W_A (SAP5) in Candida albicans chromosome 6 encodes an aspartic endopeptidase (EC 3.4.23.24) with aspartic endopeptidase activity and metal binding, belonging to the aspartic peptidase A1 family. The gene is associated with host-pathogen interactions, including transepithelial migration of symbiont in host, immune evasion, perturbation of host immune response, and anti-inflammatory response. It is linked to processes such as germ tube formation, phagocytosis, regulation of autophagy, mitochondria depolarization, and wound healing. The encoded protein localizes to the fungal-type cell wall, extracellular vesicles, and fungal biofilm matrix. Clinically, SAP5 is associated with oral and vaginal candidiasis, peritonitis, and disseminated candidiasis in mammalian models including humans, rats, guinea pigs, and mice. Studies of related genes in other species link the SAP family to increased virulence and loss of pathogenicity.