PLB2 — Candida albicans

Summary

C6_02000W_A (PLB2) in Candida albicans chromosome 6 encodes a protein with a lysophospholipase catalytic domain and acyltransferase/lysophospholipase domain, exhibiting phospholipase A2 and phosphatidylcholine lysophospholipase A1 activities (EC 3.1.1.5). The gene is associated with host invasion, migration in host, germ tube formation, hyphal growth, biofilm formation, morphogenesis, phagocytosis, secretion, cell death, phosphatidylcholine acyl-chain remodeling, phosphoglyceride catabolism, glucan anabolism, and sensitization. The product localizes to the periplasm, extracellular vesicles, fungal-type cell wall, plasma membrane, ER, cytosol, and extracellular space. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity in models of candidiasis and peritonitis.