RBF1 — Candida albicans

Summary

C6_02840C_A (RBF1, also known as SPT20 or CaSPT20) on chromosome 6 of Candida albicans encodes a protein with DNA binding and transcription coactivator activity, and is associated with telomeric repeat binding. The gene is linked to the Mediator complex and localises to the nucleus, cytoplasm and telomeric chromosome regions. RBF1 is associated with positive regulation of transcription by RNA polymerase II, as well as with filamentous and hyphal growth, biofilm formation, invasive growth, morphogenesis, cell wall biogenesis, and signal transduction. It is also associated with mtDNA replication, regulation of chitin anabolism, amino acid breakdown, osmotic response, phospholipid anabolism, and rRNA processing. Related genes in other species encode Spt20-like SEP domain-containing proteins.