GPD1 — Candida albicans

Summary

C6_02010C_A, also known as GPD1 or GPD2 in Candida albicans, encodes a glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.8). This gene is associated with glycerol-3-phosphate breakdown and metabolism, as well as glycerol anabolism, fermentation, and carbohydrate metabolism. It is linked to the osmotic response, morphogenesis, cell cycle modulation, and homeostasis. GPD1 is also associated with response to host, immune evasion, and symbiont-mediated suppression of host complement activation. The protein localizes to the cytosol, nucleus, peroxisome, fungal-type cell wall, extracellular vesicles, and biofilm matrix. Phenotypic associations include decreased hypoosmotic stress resistance, absent desiccation and hyperosmotic stress resistance, altered cell cycle progression, and increased anaerobic and fermentative growth.