CBP3 — Candida albicans

Summary

CaCBP3 (C6_02460C_A) on chromosome 6 of Candida albicans encodes a protein belonging to the ubiquinol-cytochrome c chaperone CBP3 family, with ribosome and mRNA binding activities. The gene is associated with mitochondrial cytochrome bc(1) complex assembly, positive regulation of mitochondrial translation, aerobic respiration, electron transport chain, and fermentation. It is linked to cell death, pore formation, protein stabilization, and digestion. The product localizes to mitochondria, the mitochondrial inner membrane, and the Cbp3p-Cbp6 complex. Phenotypic associations include absent respiratory metabolism, increased biofilm formation, decreased pseudohyphal growth, increased mitophagy, decreased apoptosis, increased osmotic stress resistance, decreased cell size, abnormal cellular morphology, and altered cell cycle progression. Studies of related genes in other species link the family to oxidative stress response and abnormal sporulation.