ACF2 — Candida albicans

Summary

C6_01690W_A (ACF2, also known as ENGL1, ENG1, ENG2, CaACF2, GH81-1, CaDSE4, CaGH81-1, CaENG1, CaENGL1, DSE4, CaENG2) on Candida albicans chromosome 6 encodes an endo-1,3(4)-beta-glucanase (EC 3.2.1.39) with glucan exo-1,3-beta-glucosidase and glucan endo-1,3-beta-D-glucosidase activities, belonging to the GH81_N and GH81_C domain families. The gene is associated with fungal-type cell wall 1,3-beta-glucan metabolism, cell wall polysaccharide breakdown, primary cell septum hydrolysis, septum digestion after cytokinesis, bipolar cell growth, ascospore liberation, adhesion of symbiont to host cell, response to host, immune evasion, IL-1 production, immune response, biofilm formation, and cell wall organization. It localizes to the primary cell septum, division septum, cellular bud scar, ascus epiplasm, mating projection actin fusion focus, cross wall, cell cortex, and fungal-type cell wall. Phenotypic associations include abnormal filamentous growth, decreased biofilm formation, decreased mating efficiency, abnormal sporulation, increased resistance to enzymatic treatment, and decreased acquired thermotolerance.