PLB1 — Candida albicans

Summary

Candida albicans PLB1 (C6_01990W_A) encodes a lysophospholipase with phospholipase A2 activity, belonging to the acyltransferase/lysophospholipase family and containing a LysoPLipase catalytic domain. The gene is associated with multiple infection-related processes including hyphal growth, germ tube formation, biofilm formation, morphogenesis, host invasion, migration in host, and tube formation. It has been linked to immune and inflammatory responses, wound healing, secretion, release of cytochrome c from mitochondria, and phosphatidylcholine acyl-chain remodeling. The product localizes to the periplasm, plasma membrane, endoplasmic reticulum, cytosol, extracellular vesicles, and fungal-type cell wall. PLB1 is also associated with candidiasis and disseminated candidiasis in mouse models. Studies of related genes in other species link the family to peritonitis and, in some cases, unaffected pathogenicity.