PAR1 — Candida albicans

Summary

C6_01320W_A (PAR1/TRA1) in Candida albicans encodes a protein with Tra1_central, Tra1_ring, DDR_Repair_Kinase, PIK-rel_kinase_FAT, PIK_FAT, FATC_dom, PI3/4_kinase_cat_sf, PI3/4_kinase_cat_dom, ARM-type_fold, and Kinase-like_dom_sf domains, and is annotated with histone H2A kinase activity, histone acetylase activity, protein complex binding, structural molecule activity, chromatin adaptor, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, and ATP binding. The gene is associated with TORC2 signaling, DNA damage response and signal transduction, regulation of double-strand break repair, meiotic G2/MI DNA replication checkpoint, mitotic G2 DNA damage checkpoint, pachytene checkpoint, S-M checkpoint, and mitotic DNA damage checkpoint. It is linked to ergosterol metabolism, cytokine production, IL-8 production, phagocytosis, regulation of autophagy, and downregulation of macroautophagy. The product localizes to the TOR complex, ATR-ATRIP complex, TIP60 histone acetylase complex, SWR-C, nucleolus, and nuclear chromosome. Phenotypic associations include decreased cell cycle progression rate, absent X-ray resistance, decreased hypoosmotic stress resistance, absent