HOC1 — Candida albicans

Summary

C6_01390W_A (HOC1, also known as OCH1) in Candida albicans encodes a protein in the Och1-like family with glycolipid 6-alpha-mannosyltransferase and 1,6-alpha-mannosyltransferase activities. The gene is associated with N-glycan processing, mannan and cell wall mannoprotein anabolism, cell wall biogenesis and assembly, protein secretion, biofilm formation, filamentous growth in response to starvation, morphogenesis, and the cellular response to heat. It is linked to cytokine production, including IL-10 production, and immune response. The encoded protein localises to the Golgi complex, ER membrane, and mannan polymerase complexes. Associations with phenotypes include abnormal budding, bipolar budding pattern, Golgi morphology, septum and spore wall formation, absent or decreased shmoo formation, decreased spore germination, delayed mitotic cell cycle, sterile mating, and absent filamentous growth. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.