NCA3 — Candida albicans

Summary

C6_00820W_A (NCA3, also known as SUN41) on Candida albicans chromosome 6 encodes a SUN family protein with glucan endo-1,3-beta-D-glucosidase activity, beta-glucosidase activity, and sugar binding. This gene is associated with fungal-type cell wall organization or biogenesis, cell wall biogenesis, cell morphogenesis, 1,3-beta-glucan breakdown, septum digestion after cytokinesis, and flocculation. It is linked to response to host, adhesion of symbiont to host, single-species biofilm formation in or on host organism, immune evasion, and innate immunity. Associations also include oxidative phosphorylation, autophagy of mitochondrion, regulation of DNA replication, and vitamin anabolism. The protein localizes to the fungal-type cell wall, fungal biofilm matrix, extracellular vesicle, and mitochondrial inner membrane. Phenotypic associations include increased virulence, decreased polyploidy, abnormal aneuploidy, delayed autophagy, decreased chitin deposition, increased cell death, and altered budding patterns.