GPX1 — Candida albicans

Summary

Candida albicans GPX1 (also known as HYR1, CaGPX1, CaGPX2, CaHYR1) on chromosome 6 encodes a phospholipid-hydroperoxide glutathione peroxidase with thioredoxin-dependent peroxiredoxin activity (EC 1.11.1.24), belonging to the thioredoxin-like superfamily. The gene is associated with cell redox homeostasis, oxidative stress response, and cellular detoxification of hydrogen peroxide. It is linked to numerous biological processes including germ tube formation, inflammatory response, immune response, cytokine production, opsonization, phagocytosis, T cell polarization, wound healing, and memory. GPX1 is associated with mitochondrial function, ATP anabolism, lipid oxidation, and peptidyl-cysteine oxidation. Localization evidence places the product in mitochondria, cytoplasm, cytosol, and nucleus. Phenotypic associations include increased lifespan and viability, altered cell cycle progression, abnormal redox state, increased acid pH resistance, decreased hypoosmotic stress resistance, and effects on vegetative growth, nutrient uptake, and protein secretion.