PMB — Candida albicans

Summary

C6_01060C_A (PMB, also known as CAN2, ALP1, or LYP1) in Candida albicans encodes a basic amino acid permease with transmembrane transporter activity for L-arginine, L-histidine, L-lysine, and L-proline, and belongs to the APC_YAT and amino acid permease domain families. The gene is associated with nitrogen catabolite repression, amino acid membrane transport, proline import, SAM transport, response to heat and stress, biofilm formation, plasma membrane organization, and glucan and sphingolipid anabolism. It localizes to the plasma membrane, eisosome, extracellular vesicle, Golgi, and ER. Phenotypic associations include abnormal nitrogen utilization, increased pseudohyphal growth, decreased apoptosis, altered cell cycle progression, increased aneuploidy, decreased nutrient uptake, and increased freeze-thaw resistance. Studies of related genes in other species link the family to reduced virulence and altered biofilm formation.