PMB — Candida albicans

Summary

C6_00960W_A (PMB, also known as CAN1, ALP1, LYP1) in Candida albicans encodes a basic amino acid permease with transmembrane transporter activity for L-arginine, L-lysine, L-histidine, and L-proline, belonging to the APC_YAT and amino acid permease families. The gene is associated with nitrogen catabolite repression, amino acid membrane transport, plasma membrane organization, response to heat and stress, single-species biofilm formation, and glucan and sphingolipid anabolism. It localizes to the plasma membrane, eisosome, Golgi complex, and ER. Phenotypic associations include abnormal nitrogen source utilization, increased pseudohyphal growth, decreased apoptosis and cell death, altered cell cycle progression, increased aneuploidy, decreased nutrient uptake, and abnormal plasma membrane morphology. Studies of related genes in other species link the family to reduced virulence and altered biofilm formation.