PMB — Candida albicans

Summary

C6_00830C_A (PMB, also known as CAN3) in Candida albicans encodes a basic amino acid permease with transmembrane transporter activity for L-proline, L-histidine, L-arginine, and L-lysine, and belongs to the APC_YAT and amino acid permease families. The gene is associated with nitrogen catabolite repression, amino acid membrane transport, proline import, SAM transport, and basic amino acid transport. It is also associated with plasma membrane organization, response to heat and stress, single-species biofilm formation, glucan and sphingolipid anabolism, and localization to the eisosome, extracellular vesicles, Golgi, ER, and plasma membrane. Phenotypic associations include abnormal nitrogen utilization, increased pseudohyphal growth, decreased apoptosis, altered cell cycle progression, increased aneuploidy, and decreased nutrient uptake. Studies of related genes in other species link the family to reduced virulence and altered biofilm formation.