GPX1 — Candida albicans

Summary

GPX1 (also known as GPX2, HYR1, CaHYR1, CaGPX2, CaGPX1) on Candida albicans chromosome 6 encodes a phospholipid-hydroperoxide glutathione peroxidase with thioredoxin-dependent peroxiredoxin activity (EC 1.11.1.24), belonging to the GPX_CS and thioredoxin-like superfamily. The gene is associated with cell redox homeostasis, oxidative stress response, and cellular detoxification of hydrogen peroxide, as well as with mitochondrial localisation. It has been linked to numerous phenotypes including increased viability and vegetative growth, decreased hypoosmotic stress resistance, altered cell cycle progression, abnormal redox state, increased acid pH resistance, and increased lifespan. GPX1 is also associated with immune response, cytokine production, inflammatory response, germ tube formation, and opsonization, and has been associated with disseminated candidiasis. Related genes in other species link the family to turgor pressure.