RTI1 — Candida albicans

Summary

C6_00510C_A (RTI1, RAD52) on Candida albicans chromosome 6 encodes a member of the Rad52 family of DNA recombination and repair proteins. The product possesses DNA reannealing, DNA end binding, recombinase, and damaged DNA binding activities, and localizes to the nucleus, chromatin, mitochondria, and sites of double-strand breaks. RTI1 is associated with double-strand break repair via single-strand annealing, break-induced replication, recombinational repair, meiotic joint molecule formation, telomere maintenance via recombination, and gene conversion at the mating-type locus. It is also linked to cellular responses to ionizing radiation and UV, DNA amplification, regeneration, mitochondrial DNA repair, and downregulation of filamentous growth. Related genes in other species are linked to oxidative stress response.