CPH2 — Candida albicans

Summary

C6_00280W_A (CPH2) on Candida albicans chromosome 6 encodes a basic helix-loop-helix (bHLH) transcription factor with DNA-binding transcription activator activity, protein dimerization activity, and sterol regulatory element (SRE) binding. The gene is associated with the SREBP signalling pathway and regulation of ergosterol biosynthetic process, as well as cellular responses to hypoxia, copper, and neutral pH. CPH2 has been linked to filamentous growth of unicellular populations in response to chemical, pH, and biotic stimuli, and to biological processes involved in symbiotic interaction and phagocytosis. The encoded protein localises to the Sre1-Scp1 complex, endoplasmic reticulum membrane, nuclear envelope, Golgi membrane, chromatin, and cytoplasm. Related genes in other species link the family to sterol metabolism.