ABR1 — Candida albicans

Summary

C6_00480C_A (ABR1, FET31) in Candida albicans encodes a multicopper oxidase of the CuRO_2_Fet3-like family with ferroxidase activity and iron channel activity, and binds copper. The gene is associated with reductive iron assimilation, iron transport, cellular copper ion homeostasis, response to iron and copper, arsenate ion transmembrane transport, biofilm formation, cell death, prostaglandin and arachidonic acid metabolism, eoxin synthesis, melanin and pigment anabolism, and oxidative stress response. The product localises to the plasma membrane, the high-affinity iron permease complex, the fungal biofilm matrix, and extracellularly. Phenotypic associations include absent sporulation and spore germination, abnormal replicative lifespan, decreased pexophagy and micronucleophagy, increased alkaline pH resistance, and altered cell cycle progression. Studies of related genes in other species link the family to iron and copper sensitivity and reduced virulence.