ABR1 — Candida albicans

Summary

C6_00470C_A (ABR1, also known as FET99) in Candida albicans encodes a multicopper oxidase of the CuRO_2_Fet3-like family, possessing ferroxidase activity and iron channel activity, and binds copper. The gene is associated with multiple biological processes including reductive iron assimilation, iron ion membrane transport, cellular copper ion homeostasis, response to iron and copper, biofilm formation, cell death, melanin and pigment anabolism, prostaglandin and arachidonic acid metabolism, eoxin synthesis, and arsenate ion transmembrane transport. The encoded product localises to the plasma membrane, the high-affinity iron permease complex, the fungal biofilm matrix, and the extracellular space. Associations with traits include oxidative stress response, and phenotypes linked to ABR1 encompass altered alkaline pH resistance, decreased anaerobic and fermentative growth, abnormal replicative lifespan, absent sporulation and spore germination, and increased nutrient uptake and small molecule transport.