PRP2 — Candida albicans

Summary

C5_05370C_A (PRP2) in Candida albicans chromosome 5 encodes a DEAH-box RNA helicase with 3'-5' RNA helicase activity, ATP hydrolase activity, and second spliceosomal transesterification activity. It is associated with spliceosome complex disassembly, formation of catalytic spliceosomes for both transesterification steps, and ribosomal small subunit binding. The gene has been connected to cell cycle progression through G2/M phase transition, chromosome segregation, recovery from pheromone-induced cell cycle arrest, mating response, shmoo formation, nuclear fusion during mating, and respiratory metabolism. Additional associations include regulation of DNA replication, spindle pole body assembly, septin ring assembly, glycolytic process, osmotic response, and release of cytochrome c from mitochondria. The protein localizes to spliceosomal complexes, the SSU processome, and the nucleolus. Related genes in other species link the family to RNA helicase function.