ADH1 — Candida albicans

Summary

C5_05050W_A, symbol ADH1, on Candida albicans chromosome 5, encodes a protein with aldo-keto reductase (NAD) activity and methylglyoxal reductase activity, containing ADH-like and NAD(P)-binding domains and binding zinc. The gene is associated with methylglyoxal anabolism, glycolytic process, arginine breakdown and metabolism, nitrogen catabolite repression, and catabolite repression. It is linked to reactive oxygen species metabolic process, glutathione anabolism, response to cadmium, and cell-cycle G2 phase. ADH1 is associated with biofilm formation, germ tube and tube formation, inflammatory response, and perturbation of host immune response. Its product localises to the cytoplasm, cell wall (yeast-form and hyphal), plasmalemma, biofilm matrix, mitochondrial lumen, and extracellular. Studies of related genes in other species link these genes to similar metabolic and stress-response processes.