SFL1 — Candida albicans

Summary

C5_04830W_A (SFL1, also known as SFL2) in Candida albicans encodes a protein containing an HSF-type DNA-binding domain, with DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor binding, and phosphorelay response regulator activity. The protein localises to the nucleus, chromatin, and cytosol. SFL1 is associated with germ tube formation, biofilm formation, flocculation, quorum sensing, cell differentiation, immune evasion, response to farnesol and singlet oxygen, cellular thermotolerance, amino acid import and breakdown, and regulation of filamentous growth. Phenotypic associations include abnormal biofilm formation and flocculation, increased adhesion and nutrient uptake, decreased budding and spore germination, altered cell cycle progression, and abnormal colony shape. Studies of related genes in other species link the family to protein and phosphate content.